Effect of Immunonutrients on Oral Mucositis in Nasopharyngeal Carcinoma Patients After Che
The purpose of this study was to investigate the role of immunonutrion compared with standard nutrition in reducing oral mucositis in patients with locally advanced nasopharyngeal carcinoma.
| Condition(s) | Locally Advanced Nasopharyngeal Carcinoma |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The purpose of this study was to investigate the role of immunonutrion compared with standard nutrition in reducing oral mucositis in patients with locally advanced nasopharyngeal carcinoma. |
| Who can participate | Inclusion Criteria: 1. Eastern Cooperative Oncology Group (ECOG) performance status 0-1; 2. Age 18-70 years old, male or non-pregnant women; 3. Pathologically confirmed non-keratinizing carcinoma of the nasopharynx (differentiated or undifferentiated,WHO type II or III); 4. Newly diagnosed stage III-IVa (8th AJCC/UICC stage) NPC patients; 5. The levels of major organ function meet the following criteria: (1)Hematology: WBC ≥ 3.0 × 10\^9/L, ANC ≥ 1.5 × 10\^9/L, PLT ≥ 100 × 10\^9/L, HGB ≥ 90 g/L; (2) Liver function: ALT, AST≤2.5 times the upper limit of normal (ULN), total bilirubin ≤ 1.5 × ULN; (3) Renal function: BUN and CRE ≤ 1.5 × ULN or an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min (calculated using the Cockcroft-Gault equation); (4) Adequate coagulation function: defined a |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Lead sponsor | First Affiliated Hospital of Guangxi Medical University |
| Locations | Fuzhou, Fujian, China; Fuzhou, Fujian, China; Guangzhou, Guangdong, China; Guangzhou, Guangdong, China; Huizhou, Guangdong, China; Guilin, Guangxi, China (+14 more sites) |
| Start date | 2023-06-12 |
| NCT ID | NCT05892354 |
| Official listing | https://clinicaltrials.gov/study/NCT05892354 |