Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke
Stroke is a leading cause of disability and the second leading cause of death worldwide. Most strokes are ischemic, caused by acute arterial occlusion. Post-stroke treatment focuses on secondary prevention and rehabilitation, but few treatments address functional recovery. Creatine, a supplement known for improving phy
| Condition(s) | Stroke, Ischemic |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Stroke is a leading cause of disability and the second leading cause of death worldwide. Most strokes are ischemic, caused by acute arterial occlusion. Post-stroke treatment focuses on secondary prevention and rehabilitation, but few treatments address functional recovery. Creatine, a supplement known for improving physical performance, may aid in the recovery of stroke patients, reducing sarcopenia and improving strength among other effects. This pilot study will investigate the effectiveness of creatine supplementation in enhancing physical and functional recovery in ischemic stroke patients. The study will involve a randomized, double-blind clinical trial comparing creatine monohydrate to a placebo. |
| Who can participate | Inclusion Criteria: * Age between 18 and 80 years * Recent diagnosis of ischemic stroke (from 24 hours to 5 days) . * Neurological deficit due to the stroke that affects mobility (paresis and/or ataxia) and requires motor rehabilitation. * Ability to understand and sign the informed consent form, or failing that, have sufficient support to carry out the correct follow-up of the study. Exclusion Criteria: * Moderate-severe disability prior to stroke, defined by an mRS\>2. * Unstable or severe clinical situation that prevents active rehabilitation. * Neurological deficit due to stroke that prevents walking without help from another person. The use of support with a cane, crutch or walker is permitted. * Moderate or severe dysphagia that makes therapeutic adherence difficult. * Use of creatin |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Lead sponsor | Fundació d'investigació Sanitària de les Illes Balears |
| Locations | Palma de Mallorca, Balearic Islands, Spain |
| Start date | 2024-09-27 |
| NCT ID | NCT06576466 |
| Official listing | https://clinicaltrials.gov/study/NCT06576466 |