Effect of Transcranial Magnetic Stimulation on Visual Functions of Adult Amblyopia: a Prel
Amblyopia, with a prevalence rates of 3% in adult population, is a common cause of vision impairment. It is characterized by impaired vision in one or both eyes because of disruption of normal visual stimuli and underdevelopment of the visual cortex, leads to lifelong visual deficits affecting both monocular and binocu
| Condition(s) | Amblyopia |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Amblyopia, with a prevalence rates of 3% in adult population, is a common cause of vision impairment. It is characterized by impaired vision in one or both eyes because of disruption of normal visual stimuli and underdevelopment of the visual cortex, leads to lifelong visual deficits affecting both monocular and binocular visual function. Common causes of amblyopia include refraction error, anisometropia, strabismus and visual deprivation arising from ptosis or congenital cataract. Our previous studies had shed light on the relationship between abnormal early visual experience, and development of later amblyopia and possible neural developmental disorders. Functional recovery is difficult when neuroplasticity slows down at the end of the critical period. To date, there is no established ef |
| Who can participate | Inclusion Criteria: 1. Adult amblyopia participants, aged 20-50 years old. 2. Based on inclusion criteria, there was a minimum of 2 lines difference in BCVA between the 2 eyes. 3. An amblyogenic factor and history of amblyopia treatment was recorded Exclusion Criteria: 1. Unstable vital sign 2. History of brain injury and/or head trauma 3. Neurological and psychiatric disease 4. Seizures or family history of seizure 5. Pregnancy 6. Uncontrolled migraine or the presence of metallic implants or shunt in the head or torso 7. Wide region of ischemic cicatrix, multiple sclerosis, taking tricycle antidepressants, 8. Analgesics or any drugs may decrease the threshold for inducing seizure 9. Experienced sleep disorders during the rTMS treatment 10. Severe alcoholism or taking seizure drugs 11. Sev |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Lead sponsor | National Taiwan University Hospital |
| Locations | Taipei County, Taiwan |
| Start date | 2023-01-05 |
| NCT ID | NCT05393739 |
| Official listing | https://clinicaltrials.gov/study/NCT05393739 |