Effect of Vitamin C Supplementation in Corneal Endothelial Damage in Phacoemulsification o
The goal of this clinical trial is to analyze the protective effects of oral ascorbic acid on the corneal endothelial layer undergoing oxidative stress due to phacoemulsification in patients with hard cataracts. The main questions it aims to answer are: 1. Will oral vitamin C administration provide better protection to
| Condition(s) | Endothelial Cell Loss, Corneal, Cataract and Intraocular Lens (IOL) Surgery |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this clinical trial is to analyze the protective effects of oral ascorbic acid on the corneal endothelial layer undergoing oxidative stress due to phacoemulsification in patients with hard cataracts. The main questions it aims to answer are: 1. Will oral vitamin C administration provide better protection to the corneal endothelium in hard cataract phacoemulsification by comparing preoperative and postoperative administration, preoperative only, and no administration? 2. How does oxidative stress (MDA levels) in the aqueous humour increase after oral vitamin C administration compared to no administration? 3. Will there any changes in MDA levels in the aqueous humour and blood after oral vitamin C administration compared to no administration? 4. Does MDA levels in the aqueous hum |
| Who can participate | Inclusion Criteria: * Males and females aged 60 years or older * Patients with immature senile cataracts in one or both eyes, with LOC (lens opacities classification) III nuclear opacity grade 4-6 and nuclear color grade 4-6 criteria * Patients willing to undergo phacoemulsification cataract surgery and consume the study medication as allocated, as well as participate in follow-up assessments for 7 weeks * Patients with no history of previous intraocular surgery * Patients with no history of allergy to vitamin C * Patients not routinely consuming other vitamins * Patients who agree to and sign the informed consent for the study Exclusion Criteria: \- |
| Ages | 60 Years |
| Sex | All |
| Lead sponsor | Indonesia University |
| Locations | Jakarta, DKI Jakarta, Indonesia; Cianjur, West Java, Indonesia |
| Start date | 2024-12-07 |
| NCT ID | NCT06781970 |
| Official listing | https://clinicaltrials.gov/study/NCT06781970 |