Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impai
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management. Objective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patient
| Condition(s) | Multiple Sclerosis, Electric Stimulation |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management. Objective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patients with inflammatory demyelinating disorders. Methods: This study will assess cognitive performance through standardized neuropsychological assessments before and after individualized a one-time tES intervention, measuring changes in cognitive domains including working memory, attention, executive function, and processing speed. Anticipated Results: We hypothesize that personalized transcranial electrical stimulation will demonstrate significant improvements in cognitive perfo |
| Who can participate | Inclusion Criteria: * Patients with Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis (MS), and other Central Nervous System Inflammatory Demyelinating Diseases that meet diagnostic criteria; * Patients with SDMT scores \<55 or subjective cognitive decline; * Age between 18 and 65 years, gender unrestricted; * No relapse or medication changes in the past month; * EDSS (Expanded Disability Status Scale) score ≤6; * Right-handed, native Chinese speakers with sufficient educational background to understand the test instructions; -Willing to participate and have signed informed consent.- Exclusion Criteria: * Relapse record within the past month; * Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimula |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Xuanwu Hospital, Beijing |
| Locations | Beijing, Beijing Municipality, China |
| Start date | 2024-12-31 |
| NCT ID | NCT06968039 |
| Official listing | https://clinicaltrials.gov/study/NCT06968039 |