Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without
| Condition(s) | Tobacco Use, Cigarette Smoking, Nicotine Dependence |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without relighting) cigarettes in the natural environment and will conduct in-clinic measurements of smoking topography and subjective responses for relit and non-relit cigarettes. Information on relighting patterns and smoking topography collected from each participant will be used to compare machine-measured smoke yields of key harmful constituents when their usual cigarettes are smoked with and without relighting. Hypothesis: Relit cigarettes will produce higher levels of toxicant |
| Who can participate | Inclusion Criteria: * Smoking at least 10 cigarettes/day for at least 1 year (confirmed by CO \> 8 ppm or NicAlert test of 6) * Engaging in relighting for at least half of their CPD * No smoking quit attempts in the past month nor intentions to quit in the next month * Stable medical or psychiatric conditions with systolic blood pressure \< 160, diastolic blood pressure \< 100 and heart rate \< 105 bpm Exclusion Criteria: * Participant with current or recent alcohol or drug abuse problems, use of substances of abuse (other than marijuana due to high prevalence of co-use) within the past month * Currently trying or planning to quit smoking in the next month * Planning to become pregnant, pregnant or breastfeeding. Pregnancy exclusion will be confirmed through a urine test. |
| Ages | 21 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Masonic Cancer Center, University of Minnesota |
| Locations | Minneapolis, Minnesota, United States |
| Start date | 2024-10-12 |
| NCT ID | NCT06295757 |
| Official listing | https://clinicaltrials.gov/study/NCT06295757 |