Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function
Primary progressive aphasia (PPA) is a focal dementia characterized by primary impairment of language abilities and functional disturbances associated with language. Although PPA is a progressive disorder, new techniques are being proposed to try to activate parts of the brain previously thought to be potentially inact
| Condition(s) | Aphasia, Primary Progressive |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Primary progressive aphasia (PPA) is a focal dementia characterized by primary impairment of language abilities and functional disturbances associated with language. Although PPA is a progressive disorder, new techniques are being proposed to try to activate parts of the brain previously thought to be potentially inactive, due to the possibility of "neuroplasticity". This concept refers to our brain's modularity and learning potential. Transcranial direct current stimulation is a powerful neuromodulatory technique, in which a small current is applied to the participant's scalp through the targeted positioning of an anode and a cathode. The positive or anodal stimulation of tDCS is supposed to increase neuronal activity under the electrode, while cathodal stimulation is supposed to do the o |
| Who can participate | Inclusion Criteria: * Be a male or female over the age of 18 with a primary progressive aphasia diagnosis * Available for treatment and testing sessions * able to read and speak French * Be right-handed Exclusion Criteria: * Presence of neurodevelopmental disorders or non-degenerative neurological disorders * Post-stroke aphasia * Language or cognitive disorders too severe to allow task performance or communication * Pre-existing psychiatric disorders; severe depression, schizophrenia * People with pacemakers or metal implants, epilepsy * Presence of a medical condition that represents a contraindication to tDCS * Active use of psychotropic drugs * Treatment with tDCS or TMS in the last 3 months * Additional language therapy * Pregnancy or breast-feeding |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Centre Hospitalier Universitaire de Nice |
| Locations | Nice, France |
| Start date | 2024-11-04 |
| NCT ID | NCT06473714 |
| Official listing | https://clinicaltrials.gov/study/NCT06473714 |