Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D )
To compare the prognosis of patients with hyperacute ischemic stroke (arriving at the emergency department between 4.5-6 hours of symptom onset) managed in a standard stroke unit adherent to guidelines versus managed in Emergency Stroke Unit (a new stroke unit based on low-field magnetic resonance imaging).
| Condition(s) | Ischemic Stroke, Acute |
|---|---|
| Status | Recruiting |
| Phase | Phase 3 |
| Study type | Interventional |
| Summary | To compare the prognosis of patients with hyperacute ischemic stroke (arriving at the emergency department between 4.5-6 hours of symptom onset) managed in a standard stroke unit adherent to guidelines versus managed in Emergency Stroke Unit (a new stroke unit based on low-field magnetic resonance imaging). |
| Who can participate | 1. Age ≥ 18 years; 2. Patients who arrive at the emergency department between 4.5-6 hours of symptom onset\* (\*Symptom onset is defined by the "last seen normal" principle); 3. Presenting with ischemic stroke symptoms; 4. Pre-stroke mRS score 0-1; 5. Baseline NIHSS score ≥ 5; 6. Eligible for endovascular thrombectomy; 7. Informed consent signed. Exclusion Criteria: 1. Baseline NIHSS score \< 5; 2. Unable to undergo MRI because of claustrophobia; 3. Patients with cardiac pacemaker/brain pacemaker/insulin pump implantation; 4. Definite contraindication for endovascular thrombectomy; 5. Patients with postictal hemiparesis (Todd's paralysis) or those with concomitant neurological/psychiatric conditions who are unable or unwilling to cooperate; 6. Pregnant women, nursing mothers, or reluctance |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Beijing Tiantan Hospital |
| Locations | Beijing, China |
| Start date | 2024-08-10 |
| NCT ID | NCT06522282 |
| Official listing | https://clinicaltrials.gov/study/NCT06522282 |