Enhancing Memory in CPT for PTSD
Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response
| Condition(s) | Stress Disorders, Post-Traumatic |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD. However, limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD. The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy, cognitive processing therapy (CPT), for older adults with PTSD. The ultimate goal of this line of research is to develop novel rehabilitation interventions to inc |
| Who can participate | Inclusion Criteria: * Veterans with DSM-5 diagnoses of PTSD via the Clinician Administered PTSD Scale (CAPS-5) * Age \>59 Exclusion Criteria: * daily benzodiazepine use (due to memory impairing effects) * bipolar or psychotic disorders * current suicidal ideation with plan or intent * current moderate or severe substance use disorder not in remission for \>1 mo. * severe traumatic brain injury * a Montreal Cognitive Assessment (MoCA) indicative of dementia * or other disorders that would severely limit study participation |
| Ages | 60 Years |
| Sex | All |
| Lead sponsor | VA Office of Research and Development |
| Locations | Philadelphia, Pennsylvania, United States |
| Start date | 2024-10-15 |
| NCT ID | NCT06000475 |
| Official listing | https://clinicaltrials.gov/study/NCT06000475 |