Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.
Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution. Following the injection of a hypertonic saline bolus, EIT can also assess regional pulmonary perfusion distribution, allowing evaluation of the ventilation/perfusion (V/Q) ratio. In adu
| Condition(s) | Acute Respiratory Failure |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution. Following the injection of a hypertonic saline bolus, EIT can also assess regional pulmonary perfusion distribution, allowing evaluation of the ventilation/perfusion (V/Q) ratio. In adults, protocols for assessing perfusion distribution require the injection of 10 mL of a 7.5% or 10% NaCl solution or sodium bicarbonate over a few seconds. Studies have reported good hemodynamic tolerance, adequate image quality, and no significant changes in serum sodium levels. However, this volume and sodium load are not appropriate for small children. To date, no pediatric protocol exists for assessing pulmonary perfusion distribution and the ventilation/perfusion ratio u |
| Who can participate | Inclusion Criteria: * patients \< 12 years hospitalized in pediatric intensive care * intubated, under conventional invasive mechanical ventilation and sedated * between 3 and 40 kg * with central venous access in the superior vena cava * consent signed by parents or legal guardians Exclusion Criteria: * Patients with significant leaks \> 20% around the endotracheal tube * Patients receiving spontaneous ventilation (inspiratory support, NIV, etc.) * Natremia \> 150 mmol/L at inclusion * Hyperchloremia ≥ 115 mmol/L and/or hypokaliema ≤ 3 mmol/L * Patients with intracranial hypertension * Patients with active bleeding or persistent hemodynamic instability despite amines * Patients with heart failure, uncorrected cyanotic heart disease, or a history of cardiac arrhythmia * Patients with contr |
| Ages | 12 Years |
| Sex | All |
| Lead sponsor | Hospices Civils de Lyon |
| Locations | Bron, France, France |
| Start date | 2026-05-13 |
| NCT ID | NCT07532811 |
| Official listing | https://clinicaltrials.gov/study/NCT07532811 |