Exercise Primed Stroke Rehabilitation
Stroke is a leading cause of disability in the U.S. and many Veteran stroke survivors live with severe disability. Despite recent advances in rehabilitation treatments many stroke survivors have persistent physical and mental difficulties such as reduced physical and cognitive function and depression. Developing innova
| Condition(s) | Stroke |
|---|---|
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Study type | Interventional |
| Summary | Stroke is a leading cause of disability in the U.S. and many Veteran stroke survivors live with severe disability. Despite recent advances in rehabilitation treatments many stroke survivors have persistent physical and mental difficulties such as reduced physical and cognitive function and depression. Developing innovative treatments that address these problems is necessary to improve long-term outcomes for stroke survivors. Aerobic exercise (AEx) can improve physical and cognitive function, and reduce depression. Additionally, AEx may enhance physical rehabilitation by making the brain more receptive to, and consequently improving the response to an intervention. Therefore, combining AEx with physical rehabilitation has the potential to improve multiple aspects of stroke recovery. This st |
| Who can participate | Inclusion Criteria: * experienced unilateral stroke at least 6 months prior; * voluntarily shoulder flexion of the affected arm 20 degrees with simultaneous elbow extension 10 degrees; * moderate arm movement impairment (UE Fugl-Meyer Assessment \> 21 but \< 52 points; * passive range of motion in paretic shoulder, elbow, wrist, thumb and fingers within 20 degrees of normal; * 50-90 years of age; * ability to communicate as per the therapists' judgement at baseline testing; * ability to complete and pass an exercise tolerance test; 8) Box \& Block test score of at least 3 blocks in 60 seconds with the affected arm. Exclusion Criteria: * lesion in brainstem/cerebellum as these may interfere with visual-perceptual/cognitive skills needed for motor re-learning; * presence of other neurologica |
| Ages | 50 Years to 90 Years |
| Sex | All |
| Lead sponsor | VA Office of Research and Development |
| Locations | Charleston, South Carolina, United States |
| Start date | 2021-07-01 |
| NCT ID | NCT04877444 |
| Official listing | https://clinicaltrials.gov/study/NCT04877444 |