Exercise to Slow Cardiovascular Ageing Progression
In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modi
| Condition(s) | Cardiac Ageing, Exercise, Cardiovascular |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing. |
| Who can participate | Inclusion Criteria: * Age \>=21 years old * Outdoor ambulant Exclusion Criteria: * Wheelchair or bed-bound * Dementia * Residing in sheltered or nursing home * Cancer * Participation in ongoing clinical trials that involve interventional drugs or devices * Aneurysms * Acute infections (in the last six months) * Uncontrolled thyrotoxicosis * Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise * Uncontrolled asthma or chronic lung disease * Restrictive lung disease |
| Ages | 21 Years to 100 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | National Heart Centre Singapore |
| Locations | Singapore, Singapore, Singapore |
| Start date | 2023-05-01 |
| NCT ID | NCT05775484 |
| Official listing | https://clinicaltrials.gov/study/NCT05775484 |