Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life. Prefrailty represents an early stage where interventions may prevent or reverse these declines. This study aims to eva
| Condition(s) | Pre-Frailty, Aging |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life. Prefrailty represents an early stage where interventions may prevent or reverse these declines. This study aims to evaluate whether a 12-week combined Synbiotic enriched oral nutritional supplement and supervised exercise program can improve muscle strength and mass, gut microbiome composition, immune function, and cognitive performance in prefrail adults aged 50-80 years. |
| Who can participate | Inclusion Criteria 1. Singapore residents of all ethnic groups 2. Adults aged 50-80 years (both male and female) 3. Body mass index (BMI) ≥18 kg/m² 4. Classified as Prefrailty according to Fried frailty criteria 5. Willing and able to attend all data collection visits and to comply with the exercise and supplementation protocols. 6. Able and willing to provide written informed consent. Exclusion Criteria: 1. Current use of supplements containing: Bifidobacterium longum 536 (BB536) like Kordel's BB536 bifidus; Bifidobacterium longum such as GniiB immunity; GOS (Galacto-oligosaccharides); FOS (Fructo-oligosaccharides); Inulin or any commercial healthy-aging powdered milk products 2. BMI \>30 kg/m2 3 Being on special diets including but not limited to ketogenic diets or diets prescribed by a |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Lead sponsor | National University of Singapore |
| Locations | Singapore, Singapore |
| Start date | 2025-09-22 |
| NCT ID | NCT07454616 |
| Official listing | https://clinicaltrials.gov/study/NCT07454616 |