Exploring the Benefit of Topical Capsaicin in Treating Pain From Chemo-induced Peripheral
To learn if topical capsaicin can help relieve pain from CIPN and improve gait (the pattern of walking) in patients.
| Condition(s) | Peripheral Neuropathy Due to Chemotherapy |
|---|---|
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Study type | Interventional |
| Summary | To learn if topical capsaicin can help relieve pain from CIPN and improve gait (the pattern of walking) in patients. |
| Who can participate | Inclusion Criteria: * Participants diagnosed with pain of the lower extremity from chronic (\>90 days duration) CIPN (due to either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds), seen at MD Anderson Cancer Center * Participants reporting baseline pain ≥ 4 (0-10 scale, NRS) * Participants age 18+ * Participants who have completed chemotherapy within the last year at the time of enrollment. Exclusion Criteria: * Participants with cognitive dysfunction * Participants with recent history (\<6 months) of drug or alcohol abuse * Participants with open skin lesion or undergoing antibiotic therapy for local for systemic infection * Participants with allergies to capsaicin or adhesives * Pregnant participants |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | M.D. Anderson Cancer Center |
| Locations | Houston, Texas, United States |
| Start date | 2025-12-11 |
| NCT ID | NCT06744816 |
| Official listing | https://clinicaltrials.gov/study/NCT06744816 |