External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abd
Postoperative pain after laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) is often severe, and inadequate analgesia may lead to increased opioid use, opioid dependence, and poor functional recovery. Current analgesic techniques such as neuraxial block have safety conc
| Condition(s) | Abdominal Surgery, Postoperative Pain |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Postoperative pain after laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) is often severe, and inadequate analgesia may lead to increased opioid use, opioid dependence, and poor functional recovery. Current analgesic techniques such as neuraxial block have safety concerns (e.g., hypotension, neurological injury), while transversus abdominis plane (TAP) block is ineffective for blocking the lateral cutaneous branches of intercostal nerves in the upper abdomen. The External Oblique Intercostal Plane Block (EOIB) is a novel regional block technique that has shown promise in reducing postoperative opioids and pain in small-scale studies, but evidence for its use in major upper abdominal surgery is limited. This randomized controlled trial (RC |
| Who can participate | Inclusion Criteria: * Obtain written informed consent from participants or their legal representatives * Age between 18 and 85 years * American Society of Anesthesiologists (ASA) physical status classification I-III * Scheduled for elective laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) * Expected surgical duration ≥ 2 hours * Ability to use the intravenous patient-controlled analgesia (IV PCA) system Exclusion Criteria: * Hepatic disease (liver enzyme levels ≥ 2× the upper limit of normal) * Renal disease (serum creatinine levels ≥ 2× the upper limit of normal) * Allergy to local anesthetics or known study-related drugs * Pregnancy or lactation * Low surgical incision site (not involving the upper abdominal wall innervated by T6-T10 ne |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Lead sponsor | Jun Zhang |
| Locations | Shanghai, China |
| Start date | 2026-02-01 |
| NCT ID | NCT07331441 |
| Official listing | https://clinicaltrials.gov/study/NCT07331441 |