Fatigue and Cognitive Dysfunction After Allogeneic Stemcell Transplantation, Prospective P
This study is the academic study and continuation and further development of a prior project under the leadership of Professor LeBlanc. Patients undergoing allogenic stem cell transplantation are followed up in the outpatient clinic. Here, patients are offered participation the fatigue study measuring both fatigue and
| Condition(s) | Fatigue, Cognitive Dysfunction |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study is the academic study and continuation and further development of a prior project under the leadership of Professor LeBlanc. Patients undergoing allogenic stem cell transplantation are followed up in the outpatient clinic. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Previous study by Boberg et al suggested distinct mRNA and proteomic profiles segregating fatigued from non-fatigued patients as well as patients with or without cognitive impairment. A larger well-defined patient cohort is necessary to confirm these results. Investigators aim to identify specific sets of proteins in the CSF that can serve as potential biomarkers of cognitive dysfunction and/or fatigue. This will |
| Who can participate | Inclusion Criteria: * status 1-5 years after HSCT * no known CNS disorders or psychiatric disturbances Exclusion Criteria: * prior TBI or CNS irradiation / intrathecal therapy * known neurological or psychiatric disorder * time less then 1 year or over 5 years after transplantation |
| Ages | 20 Years to 75 Years |
| Sex | All |
| Lead sponsor | Karolinska Institutet |
| Locations | Stockholm, Sweden |
| Start date | 2024-02-22 |
| NCT ID | NCT06363396 |
| Official listing | https://clinicaltrials.gov/study/NCT06363396 |