FSRT Combines With Bevacizumab for Multiple Brain Metastases in Lung Adenocarcinoma
For non-small cell lung cancer brain metastases, stereotactic radiotherapy is gradually replacing whole brain radiotherapy as the standard treatment. When patients have multiple brain metastases or larger tumors (diameter\>2cm), single session stereotactic radiotherapy (SRS) may cause significant neurological damage, s
| Condition(s) | Multiple Brain Metastases in Lung Adenocarcinoma |
|---|---|
| Status | Recruiting |
| Phase | Phase 3 |
| Study type | Interventional |
| Summary | For non-small cell lung cancer brain metastases, stereotactic radiotherapy is gradually replacing whole brain radiotherapy as the standard treatment. When patients have multiple brain metastases or larger tumors (diameter\>2cm), single session stereotactic radiotherapy (SRS) may cause significant neurological damage, so fractionated stereotactic radiotherapy (FSRT) is often used. The recent objective remission rate of FSRT is about 50%, and the 1-year intracranial control rate is about 45%, but intracranial progression remains the main factor affecting long-term survival of patients. Bevacizumab is a recombinant humanized monoclonal antibody against vascular endothelial growth factor, which can improve the efficacy of cranial radiotherapy by normalizing neovascularization and improving the |
| Who can participate | Inclusion Criteria: * Age ≥ 18 years old; * Cellular or histopathological confirmation of lung adenocarcinoma; * Prior to enrollment, brain enhanced magnetic resonance imaging shows (1) 1-2 brain metastases, with at least one measuring ≥3 cm in diameter; or (2) 3-10 brain metastases, with at least one measuring ≥2 cm in diameter; or (3) 11-20 brain metastases; and deemed unsuitable for single-session SRS by radiation oncologists; * At the time of enrollment, the extracranial disease status is stable; * Eastern Cooperative Oncology Group (ECOG) physical fitness status score 0-2 points * Normal liver, kidney, and bone marrow function within 14 days prior to enrollment: peripheral blood white blood cell count ≥ 4 × 10\^9/L; neutrophil count ≥ 1.5 × 10\^9/L, platelet count ≥ 100 × 10\^9/L, hem |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Sun Yat-Sen University Cancer Center |
| Locations | Guangzhou, Guangdong, China |
| Start date | 2025-06-30 |
| NCT ID | NCT07058428 |
| Official listing | https://clinicaltrials.gov/study/NCT07058428 |