Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory load
| Condition(s) | Obstructive Sleep Apnea Syndrome |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze. |
| Who can participate | Inclusion criteria : 1. OSAS patients * severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h * without CPAP treatment 2. Non-OSAS patients * absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11) Non-inclusion criteria : * \< 18 years old * \>75 years old * left-handed * BMI\> 40 kg/m² * another sleep disorder * central component of sleep apnea syndrome (central apnea index\> 5 / h) * current or past neurological pathology * respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia) * MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.) * taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.), * uncorrected sensory i |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | CHU de Reims |
| Locations | Reims, France |
| Start date | 2023-03-02 |
| NCT ID | NCT05147649 |
| Official listing | https://clinicaltrials.gov/study/NCT05147649 |