Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at
| Condition(s) | Coronary Heart Disease |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, as well as identify new biomarkers for CVD. |
| Who can participate | Inclusion Criteria: * adult patients of both sexes over 18 years of age * Caucasian * undergoing elective coronary artery bypass grafting (CABG) * provided written informed consent Exclusion Criteria: * emergency surgery * sepsis or severe systemic inflammation before surgery * severe renal or hepatic insufficiency * immunosuppression * serious comorbidities (e.g., active cancer) * therapies that could affect oxidative stress (e.g., high doses of corticosteroids) |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Josip Juraj Strossmayer University of Osijek |
| Locations | Osijek, Croatia |
| Start date | 2025-10-01 |
| NCT ID | NCT07451873 |
| Official listing | https://clinicaltrials.gov/study/NCT07451873 |