Gut Microbiota of Preterm Infants and Full-term Infants at Early Life
The aim of this study is to obtain a longitudinal view of the gut microbial establishment of a cohort of 51 preterm (PT) infants compared to 50 full-term (FT) infants from birth to 90 days of age, and to identify key clinical factors that affect the establishment of neonatal microbiome. The hypothesis of the investigat
| Condition(s) | Preterm Infant, Gut Microbiome |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The aim of this study is to obtain a longitudinal view of the gut microbial establishment of a cohort of 51 preterm (PT) infants compared to 50 full-term (FT) infants from birth to 90 days of age, and to identify key clinical factors that affect the establishment of neonatal microbiome. The hypothesis of the investigators is that the gut microbiota progression of PT group and FT group is different in diversity and composition. Antibiotics and its usage duration is likely the main factor disturbing the colonization and development of the gut microbiome of PT infants. |
| Who can participate | Inclusion Criteria: Preterm infants 1. gestational age \<37 weeks; 2. no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis; 3. hospital stay \> 7 days; Exclusion criteria: 1. NICU stay less than 7 days 2. Necrotizing enterocolitis infant Control group: 1. Full-term healthy infants; 2. gestational age \>37 weeks; 3. vaginally born; 4. no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis. |
| Ages | 1 Day to 4 Months |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine |
| Locations | Shanghai, China |
| Start date | 2014-07-20 |
| NCT ID | NCT03373721 |
| Official listing | https://clinicaltrials.gov/study/NCT03373721 |