HIV and Changes in the Gut Microbiome After Changes in Antiretroviral Therapy (ART)
This is a study that aims to contribute to the understanding of how antiretroviral therapy effects the gut microbiome which, if known, could inform decisions about drug choices at an individual level. The gut health is extremely important for all aspects of a persons wellbeing both at the level of the body and the brai
| Condition(s) | HIV Infections |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This is a study that aims to contribute to the understanding of how antiretroviral therapy effects the gut microbiome which, if known, could inform decisions about drug choices at an individual level. The gut health is extremely important for all aspects of a persons wellbeing both at the level of the body and the brain. In recent years there has been much interest and better understanding of the role of the bacteria, viruses and other microorganisms that live in the human gut (the gut microbiome). It is known that disturbing the balance between the different species of bacteria in the gut can have consequences including diarrhoea, inflammatory and autoimmune conditions and has also been linked to obesity. There are big differences in the gut microbiome composition seen in people with untr |
| Who can participate | Inclusion Criteria: * Aged ≥18 years. * Willing to undergo stool sample collection on two occasions. * Able to give written, informed consent. * Have evidence of HIV infection * Have been on stable antiretroviral treatment for the previous ≥12months. * Planning to switch ART regimen from one class of drugs or delivery method to another. Exclusion Criteria: * HIV viral load \>50 copies/ml blood |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | University of Manchester |
| Locations | Manchester, Greater Manchester, United Kingdom |
| Start date | 2024-05-17 |
| NCT ID | NCT06100211 |
| Official listing | https://clinicaltrials.gov/study/NCT06100211 |