Host-Diet-Gut Interaction Post Vegan Diet in Pediatric Autoimmune Hepatitis.
Pediatric autoimmune liver diseases (AILDs), including autoimmune hepatitis (AIH) and overlap syndromes like sclerosing cholangitis, are among the most common chronic liver conditions in the pediatric population. Currently, the treatment for AIH often involves long-term use of immunosuppressive therapy, which carries r
| Condition(s) | Autoimmune Hepatitis |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Pediatric autoimmune liver diseases (AILDs), including autoimmune hepatitis (AIH) and overlap syndromes like sclerosing cholangitis, are among the most common chronic liver conditions in the pediatric population. Currently, the treatment for AIH often involves long-term use of immunosuppressive therapy, which carries risks of severe side effects both in the short and long term. Due to these potential adverse effects, there is a critical need to explore alternative therapies that can modulate autoimmunity and potentially reduce or eliminate the dependence on immunosuppressive drugs. Autoimmune diseases, including AIH, typically arise in genetically predisposed individuals after exposure to certain environmental factors, leading to a breakdown in self-tolerance.The gut microbiome plays a cru |
| Who can participate | Inclusion Criteria: 1. Cases diagnosed as Autoimmune hepatitis (AIH). 2. Controls are healthy subjects. Exclusion Criteria: 1. Recent (\< 6 weeks) exposure to oral or intravenous antibiotics, probiotics/prebiotics, proton pump inhibitors, or herbal medicines. 2. Any history of malignancy or any gastrointestinal tract surgery. 3. Recent (\< 2 weeks) gastrointestinal infection. 4. Any dietary allergies . |
| Ages | 0 Years to 18 Years |
| Sex | All |
| Lead sponsor | Institute of Liver and Biliary Sciences, India |
| Locations | New Delhi, National Capital Territory of Delhi, India |
| Start date | 2026-02-11 |
| NCT ID | NCT07118657 |
| Official listing | https://clinicaltrials.gov/study/NCT07118657 |