HTL0039732 in Participants With Advanced Solid Tumours
The purpose of this trial is to evaluate a new drug, HTL0039732, that will be administered on its own (as a monotherapy) and in combination with atezolizumab or with other approved anti-cancer therapies, in participants with advanced solid tumours.
| Condition(s) | Neoplasms, Prostatic Neoplasms, Castration-Resistant, Stomach Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Colorectal Neoplasms, Pancreatic Neoplasms, Lung Neoplasms, Urinary Bladder Neop |
|---|---|
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Study type | Interventional |
| Summary | The purpose of this trial is to evaluate a new drug, HTL0039732, that will be administered on its own (as a monotherapy) and in combination with atezolizumab or with other approved anti-cancer therapies, in participants with advanced solid tumours. |
| Who can participate | Inclusion Criteria: 1. Written (signed and dated) informed consent and capable of co-operating with investigational medicinal product administration and follow-up. 2. Phase 1, dose escalation phase Part A (HTL0039732 monotherapy): * Histologically or cytologically proven advanced solid tumour, refractory to conventional treatment, or for which no further conventional therapy is considered appropriate by the Investigator or is declined by the potential participant. * At least 1 measurable lesion according to RECIST v1.1, which (in the Investigator's opinion) has had objective radiological progression on or after the last therapy, or at least one assessable lesion e.g. pleural or peritoneal thickening that does not fulfil RECIST v1.1 criteria for measurable disease. a. Consent for fresh tumo |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Cancer Research UK |
| Locations | Cambridge, United Kingdom; Cardiff, United Kingdom; Liverpool, United Kingdom; London, United Kingdom; Manchester, United Kingdom |
| Start date | 2023-07-13 |
| NCT ID | NCT05944237 |
| Official listing | https://clinicaltrials.gov/study/NCT05944237 |