Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcin
Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main
| Condition(s) | Head Neck Cancer, Oropharyngeal Neoplasms |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main goal of this observational study is to explore the prevalence, risk factors, and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy. This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population, identify risk factors, and any biologically driven mechanisms causing HNSCC. |
| Who can participate | Inclusion Criteria: 1. Patient Age: adult (\> 18 years) 2. Head and neck squamous cell carcinoma diagnosed by biopsy (Histopathology confirmed HNSCC). 3. Diagnosed cases specific Head-Neck sub-sites: (oral cavity, oropharynx, hypopharynx, larynx, tongue) 4. Patient's Consent Exclusion Criteria: 1. Patient Age: children (\< 18 years) 2. Cancers of any part of the body other than the head-neck region. 3. People without HNSCC 4. Any chronic diseases, genetic diseases, acute/chronic infectious diseases, etc. - |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh |
| Locations | Dhaka, Dhaka Division, Bangladesh |
| Start date | 2024-04-30 |
| NCT ID | NCT06642324 |
| Official listing | https://clinicaltrials.gov/study/NCT06642324 |