Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients
This single-center, randomized controlled clinical trial aims to evaluate the effectiveness of a home-based treatment using hydroxyapatite-based oral care products in adult patients with celiac disease who exhibit enamel demineralization and dentin hypersensitivity. Forty patients will be enrolled and randomly allocate
| Condition(s) | Celiac Disease, Dentin Hypersensitivity, Tooth Demineralization |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This single-center, randomized controlled clinical trial aims to evaluate the effectiveness of a home-based treatment using hydroxyapatite-based oral care products in adult patients with celiac disease who exhibit enamel demineralization and dentin hypersensitivity. Forty patients will be enrolled and randomly allocated into two parallel groups. The control group will perform home oral hygiene using only a hydroxyapatite-based toothpaste (Biorepair® Total Protection) twice daily. The trial group will follow the same regimen with the toothpaste, but will also apply a hydroxyapatite mousse (Biorepair® Plus Intensive Enamel Repair) once every evening before bedtime throughout the study period. The primary objective is to assess the reduction in dentin hypersensitivity using the Schiff Air Ind |
| Who can participate | Inclusion Criteria: * Adults (≥18 years of age) with a confirmed diagnosis of celiac disease. * Presence of enamel defects (hypomineralization or demineralization). * Presence of active carious lesions. * Self-reported dentin hypersensitivity. * Willingness to comply with the study protocol and follow-up schedule. * Written informed consent provided. Exclusion Criteria: * Age below 18 years. * Absence of confirmed celiac disease. * Poor compliance or low motivation to participate in a 6-month study. * Ongoing treatment with products affecting enamel mineralization. * Pregnancy or breastfeeding. * Participation in another clinical trial within the previous 30 days. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | University of Pavia |
| Locations | Pavia, Lombardy, Italy |
| Start date | 2025-07-30 |
| NCT ID | NCT07069127 |
| Official listing | https://clinicaltrials.gov/study/NCT07069127 |