HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU). Many ICU patients receive more oxygen than strictly necessary, and high blood oxygen levels (hyperoxemia) ar
| Condition(s) | Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness, Mechanical Ventilation |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU). Many ICU patients receive more oxygen than strictly necessary, and high blood oxygen levels (hyperoxemia) are very common. However, the immediate effects of short hyperoxic exposures on cerebral circulation and autoregulation remain poorly understood. In this study, patients who already require mechanical ventilation for medical reasons will undergo a brief and controlled increase in the oxygen delivered through the ventilator (FiO₂). During this time, we will continuously monitor blood flow in one of the main brain arteries using a non-invasive ultrasound technique called transcra |
| Who can participate | Inclusion Criteria * Adult patients aged ≥18 years * Admitted to the intensive care unit (ICU) * Intubated and mechanically ventilated for ≤72 hours * Receiving volume-controlled mechanical ventilation * Arterial partial pressure of carbon dioxide (PaCO₂) between 35 and 45 mmHg * Invasive arterial blood pressure monitoring in place * Adequate transcranial Doppler (TCD) acoustic window * Clinically judged to be suitable for a brief normobaric hyperoxic stimulus * Expected to receive one or two hyperoxic steps based on baseline FiO₂ requirements: a) Baseline FiO₂ \< 0.5: two-step hyperoxic stimulus (FiO₂ 0.5 followed by FiO₂ 1.0); b) Baseline FiO₂ ≥ 0.5: one-step hyperoxic stimulus (FiO₂ 1.0) Exclusion Criteria: * Age \<18 years * Pregnancy * Extracorporeal membrane oxygenation (ECMO) * Cont |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Erasme University Hospital |
| Locations | Brussels, Belgium |
| Start date | 2024-01-01 |
| NCT ID | NCT07377162 |
| Official listing | https://clinicaltrials.gov/study/NCT07377162 |