Imaging Biomarkers in ALS
The purpose of the study is to determine if we are able to find one or more biomarkers of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) using magnetic resonance imaging (MRI) scans at different levels, 3 tesla (3T) and 7 tesla (7T). A biomarker is a measurable characteristic that can be used a
| Condition(s) | Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The purpose of the study is to determine if we are able to find one or more biomarkers of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) using magnetic resonance imaging (MRI) scans at different levels, 3 tesla (3T) and 7 tesla (7T). A biomarker is a measurable characteristic that can be used as an indicator of a particular disease state. Identifying biomarkers of a disease can lead to a better understanding of the disease as well as improved treatments. This study will enroll patients with ALS, PLS, and healthy controls. |
| Who can participate | Inclusion Criteria: * 21 to 75 years of age inclusive. * Willing and able to give signed informed consent that has been approved by the Institutional Review Board (IRB). ALS patients: * A clinical diagnosis of possible, laboratory-supported probable, probable, or definite ALS, according to a modified El Escorial criteria. Exclusion Criteria: * Diagnosis of other neurodegenerative diseases (Parkinson disease, Alzheimer disease, etc). * Clinically significant history of unstable medical illness (unstable angina, advanced cancer, etc) over the last 30 days. * Inability to undergo MRI scanning, including but not limited to unable to remain still in an MRI scanner for more than 30 minutes, claustrophobia, presence of paramagnetic substances or pacemakers in body, weight over 300 lbs, or in the |
| Ages | 21 Years to 75 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Minnesota |
| Locations | Minneapolis, Minnesota, United States |
| Start date | 2015-09 |
| NCT ID | NCT02567136 |
| Official listing | https://clinicaltrials.gov/study/NCT02567136 |