Imaging Post-Stroke Recovery: Using MEG to Evaluate Cognition
This is a study using magnetoencephalography (MEG) to look at recovery in those with minor stroke. The investigators know that these individuals report difficulties in attention, concentration, multi-tasking, energy level, and processing speed that appear to be independent of lesion size or location. The underlying pat
| Condition(s) | Stroke, Stroke Sequelae, Stroke/Brain Attack |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This is a study using magnetoencephalography (MEG) to look at recovery in those with minor stroke. The investigators know that these individuals report difficulties in attention, concentration, multi-tasking, energy level, and processing speed that appear to be independent of lesion size or location. The underlying pathophysiology is unclear; however, anecdotally, many individuals are significantly improved by 6 months post-stroke. One hypothesis is that a single lesion, regardless of size, may disrupt the classic neural networks required for cognitive function. The investigators are currently collecting data to better characterize these difficulties and stroke patients' recovery as part of a previously approved recovery study. In this sub-study, the investigators propose to add MEG at 1 a |
| Who can participate | Inclusion Criteria: 1. Adults (≥18 years) admitted to Bayview Medical Center Neurology. 2. Evidence of acute ischemic stroke (CT or MRI)- lacunar stroke or branch occlusion (M3/A3/P3 or smaller) OR NIHSS ≤ 8 on admission. 3. Competent speaker of English (by self or family report) prior to stroke. 4. Return for follow-up 4-6 weeks post event (+/- 4 wks). 5. Cognitive deficits present on initial testing.\*\* unique to MEG study 6. Willing to travel to the University of Maryland twice for MEG.\*\* unique to MEG study 7. Fully independent functionally and able to travel to the University of Maryland unassisted.\*\* unique to MEG study Exclusion Criteria: 1. Primary intracerebral hemorrhage- as evidenced by blood on head CT or MRI. 2. Previous neurological disease (e.g., dementia, multiple scle |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Lead sponsor | Johns Hopkins University |
| Locations | Baltimore, Maryland, United States |
| Start date | 2018-07-01 |
| NCT ID | NCT04188522 |
| Official listing | https://clinicaltrials.gov/study/NCT04188522 |