Immune Homeostasis in Sepsis and Septic Shock
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
| Condition(s) | Sepsis, Immunologic Paralysis, Immunologic Suppression, Immune Deficiency |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis. |
| Who can participate | Inclusion Criteria: * sepsis/septic shock (SEPSIS-3) * age ≥18 * informed consent * inclusion within first 24hrs after development/diagnosis of septic shock Exclusion Criteria: * disagreement of the patient or legal representative with the entry into the study * patients with primary or secondary immunodeficiency * presence of active haematological malignancy or an active non-haematological malignancy |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Charles University, Czech Republic |
| Locations | Pilsen, Česká Republika, Czechia |
| Start date | 2020-09-01 |
| NCT ID | NCT04448951 |
| Official listing | https://clinicaltrials.gov/study/NCT04448951 |