Innovative Approaches to Enhance Balance and Neuroplasticity in Multiple Sclerosis
This study will evaluate the effects of combining balance training with electrical stimulation techniques in individuals with Multiple Sclerosis (MS). MS commonly impairs leg strength, coordination, and balance, increasing the risk of falls and reducing independence. The interventions include:Balance training only, Bal
| Condition(s) | Multiple Sclerosis, Mobility Limitation, Balance; Distorted, Gait |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study will evaluate the effects of combining balance training with electrical stimulation techniques in individuals with Multiple Sclerosis (MS). MS commonly impairs leg strength, coordination, and balance, increasing the risk of falls and reducing independence. The interventions include:Balance training only, Balance training with Functional Electrical Stimulation (FES), and Balance training with FES and Transcutaneous Spinal Cord Stimulation (TSCS). FES delivers small electrical pulses to leg muscles, while TSCS delivers electrical signals through the skin to stimulate the spinal cord and enhance motor control. The study will enroll up to 24 participants over a 3-year period. This trial is funded by MS Canada. Participants will be randomly assigned to one of three groups: (1) balanc |
| Who can participate | Participants will be eligible if they meet the following conditions: * Confirmed diagnosis of Multiple Sclerosis (MS) according to the revised McDonald criteria * Age ≤ 65 years * Ability to walk at least 100 meters, with or without an assistive device, and without requiring rest * Self-reported perception of impaired balance during standing or walking in daily activities Exclusion Criteria: * Participants will be excluded if they present with any of the following: * Uncorrected visual problems * Cognitive impairment affecting comprehension of instructions or completion of self-administered outcome measures * Ongoing MS exacerbation or paroxysmal vertigo * Concurrent neurological or orthopedic conditions affecting balance * Recent participation in rehabilitation therapies (physical therapy |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | University Health Network, Toronto |
| Locations | Toronto, Ontario, Canada |
| Start date | 2025-12-30 |
| NCT ID | NCT07174973 |
| Official listing | https://clinicaltrials.gov/study/NCT07174973 |