Integrated Multimodal Assessment to Optimize Diagnosis and Surgical Selection in Idiopathi
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition that can cause walking difficulties, cognitive impairment, and urinary incontinence. Although iNPH can be treated with cerebrospinal fluid (CSF) shunt surgery, diagnosis is often challenging because its symptoms and brain imaging findings may o
| Condition(s) | Idiopathic Normal Pressure Hydrocephalus |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition that can cause walking difficulties, cognitive impairment, and urinary incontinence. Although iNPH can be treated with cerebrospinal fluid (CSF) shunt surgery, diagnosis is often challenging because its symptoms and brain imaging findings may overlap with those of other neurodegenerative disorders, such as Alzheimer's disease or vascular parkinsonism. As a result, some patients may experience delayed diagnosis or may not be referred for potentially beneficial surgical treatment. This observational study aims to evaluate whether combining different types of clinical information can improve the diagnosis of iNPH and help identify patients who are more likely to benefit from surgery. The study integrates cognitive tes |
| Who can participate | Inclusion Criteria: * Age 60 years or older. * Patients with suspected idiopathic normal pressure hydrocephalus referred to the institutional diagnostic, therapeutic, and care pathway. * Ability to provide written informed consent. Exclusion Criteria: * Refusal or inability to provide informed consent. |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Lead sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico |
| Locations | Milan, Italy; Milan, Italy |
| Start date | 2026-02-11 |
| NCT ID | NCT07427836 |
| Official listing | https://clinicaltrials.gov/study/NCT07427836 |