JAK Inhibition in Ulcerative Colitis
The treatment for Ulcerative Colitis (UC) aims to achieve and maintain remission and is usually lifelong and expensive. Current available medications are unable to break the cycle of chronic inflammation, and still a significant proportion of patients will fail to respond (primary non-response) or lose response over ti
| Condition(s) | Colitis, Ulcerative |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The treatment for Ulcerative Colitis (UC) aims to achieve and maintain remission and is usually lifelong and expensive. Current available medications are unable to break the cycle of chronic inflammation, and still a significant proportion of patients will fail to respond (primary non-response) or lose response over time (secondary non-response). There is now growing evidence that there is substantial interpatient variation in the composition of the inflammation associated network of immune cells. A deeper knowledge of the patient's alterations in the mucosal immune response would help identify key drivers of inflammation and select the appropriate therapy. By analyzing the changes in the composition of immune cells induced by Janus Kinase (JAK) inhibition, we aim to obtain a better insigh |
| Who can participate | Age Ulcerative colitis active disease |
| Ages | 16 Years to 65 Years |
| Sex | All |
| Lead sponsor | Leiden University Medical Center |
| Locations | Leiden, South Holland, Netherlands |
| Start date | 2022-12-20 |
| NCT ID | NCT05456412 |
| Official listing | https://clinicaltrials.gov/study/NCT05456412 |