Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive
Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting in cell death. LBDs consists of two major clinical entities - Parkinson's disease (PD) and
| Condition(s) | Lewy Body Disease, Healthy Aging |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting in cell death. LBDs consists of two major clinical entities - Parkinson's disease (PD) and dementia with LB (DLB). Vast majority of patients with LBDs either already have mild cognitive impairment (MCI) at the time of the diagnosis or will develop it during the course of the disease. Language dysfunctions in LBDs patients with MCI are often unrecognized, which are difficult to treat, but even subtle changes might lead to impairment of social and occupational functioning with profound effect on their quality of lives. Current pharmacological or surgical strategies a |
| Who can participate | Inclusion Criteria: * right-handedness * Czech as their first language * age (60-80 years) * presence of PD-MCI (Litvan et al. 2012) or MCI-LB (McKeith et al. 2020) for LBD subjects Exclusion Criteria: * cardio pacemaker * any MRI-incompatible metal in the body * epilepsy * any diagnosed psychiatric disorders * alcohol/drug abuse * for HC group the presence of LBDs or other neurodegenerative disorder or MCI/dementia |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Masaryk University |
| Locations | Brno, Czechia |
| Start date | 2023-05-01 |
| NCT ID | NCT05847985 |
| Official listing | https://clinicaltrials.gov/study/NCT05847985 |