LDL Cholesterol TARGETs in OLDer Patients (Age≥75 Years) With ASCVD (TARGET OLD)
To determine whether treating to an LDL-C target of 25 to \<70 mg/dL is superior to an LDL-C target of 70 to \<100 mg/dL with respect to major cardiovascular events (cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization) in patients aged ≥75 years with a
| Condition(s) | Atherosclerotic Cardiovascular Disease, Older Patients, LDL Cholesterol |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | To determine whether treating to an LDL-C target of 25 to \<70 mg/dL is superior to an LDL-C target of 70 to \<100 mg/dL with respect to major cardiovascular events (cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization) in patients aged ≥75 years with atherosclerotic cardiovascular disease (ASCVD). To determine whether treating to an LDL-C target of 25 to \<70 mg/dL is non-inferior to an LDL-C target of 70 to \<100 mg/dL with respect to major safety events (hemorrhagic stroke, new-onset diabetes, muscle-related events, neurocognitive adverse events, new or recurrent cancer, cataract, or hepatic disorder \[Alanine aminotransferase (ALT)/Aspartate aminotransferase (AST) \>3× ULN, or total bilirubin \>2× ULN\]) in patients age |
| Who can participate | Inclusion Criteria: 1. Men or women ≥75 years of age 2. Diagnosis of clinical atherosclerotic cardiovascular disease (ASCVD) with one or more of the following: 1. Diagnosis of coronary heart disease (one or more of the following criteria must be satisfied): * Hospitalization for acute coronary syndrome * Treatment or hospitalization for stable angina pectoris with documented ischemia on invasive or noninvasive testing * History of myocardial infarction * History of coronary revascularization procedure (eg, percutaneous coronary intervention \[PCI\] or coronary artery bypass graft surgery \[CABG\]) * Invasive diagnostic coronary angiography indicating \>50% stenosis in at least one major epicardial coronary artery or CT-imaging (eg, CCTA/MDCT) evidence of coronary atherosclerosis (\>50% ste |
| Ages | 75 Years |
| Sex | All |
| Lead sponsor | China National Center for Cardiovascular Diseases |
| Locations | Beijing, Beijing Municipality, China |
| Start date | 2023-03-24 |
| NCT ID | NCT05765370 |
| Official listing | https://clinicaltrials.gov/study/NCT05765370 |