Leukapheresis to Obtain Plasma or Lymphocytes for Studies of HIV-infected Patients, Includ
This study will collect white blood cells and plasma for research on how the immune system controls HIV infection. The immune system of a very small group of people with HIV, called non-progressors, has been able to control HIV for long periods without antiretroviral therapy. Some immune system-related genes important
| Condition(s) | HIV |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study will collect white blood cells and plasma for research on how the immune system controls HIV infection. The immune system of a very small group of people with HIV, called non-progressors, has been able to control HIV for long periods without antiretroviral therapy. Some immune system-related genes important for this control have been identified in these patients. People living with HIV who are 18 years of age and older, documented or suspected long-term nonprogressors in generally good health may be eligible to screen for the study. Participants will undergo apheresis (a method for collecting larger quantities of certain blood components than can safely be collected through a simple blood draw) if venous access is adequate once yearly. Some may be asked to return every six month |
| Who can participate | * INCLUSION CRITERIA: 1. Adult (18 years-old or older) 2. Eligibility to undergo apheresis procedures; or, for participants who are unable to undergo apheresis, willingness to undergo blood draw for research purposes that remain within safety guidelines established by NIH policy. 3. Willingness to give informed consent for the storage of blood or tissue samples and HLA testing AND at least one of the following: * An HIV-seropositive participant categorized as an LTNP as defined by clinical and laboratory criteria, regardless of HLA class I type. * HIV-seropositive progressors * Persons who are seronegative for HIV but are family members of seropositive participants exhibiting immunologic control of HIV EXCLUSION CRITERIA: 1. Pregnant 2. Cardiovascular instability, severe anemia, inadequate |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Lead sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
| Locations | Bethesda, Maryland, United States |
| Start date | 2001-08-09 |
| NCT ID | NCT00029445 |
| Official listing | https://clinicaltrials.gov/study/NCT00029445 |