Long COVID Brain Fog: Cognitive Rehabilitation Trial
This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment. One approach will feature (A) web-based computer "games" that trains how quickly individuals process information that they receive through their senses; (B) in-lab traini
| Condition(s) | Long COVID, Brain Fog, Cognitive Impairment, Cognitive Dysfunction, Post-Acute COVID-19 Syndrome |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment. One approach will feature (A) web-based computer "games" that trains how quickly individuals process information that they receive through their senses; (B) in-lab training on everyday activities with important cognitive components, (C) procedures designed to transfer improvements in cognition from the treatment setting to everyday life, and (D) a non-invasive form of vagus nerve stimulation (VNS), i.e., trans-auricular VNS (taVNS). Component B will include work-related tasks. This approach is termed Constraint-Induced Cognitive Therapy (CICT). The other approach will feature (A) web-based computer "games" that train reaction time and eye-han |
| Who can participate | Inclusion Criteria: * \>3 months post COVID * mild or greater cognitive impairment * moderate or greater brain fog * impairment in performance of daily activities * reside in community * reliable transportation to lab * sufficiently mentally and physically fit * adequate sight and hearing * ability to follow directions, and retain information * sufficient English proficiency Exclusion Criteria: * cognitive impairment due to developmental disability, psychiatric disorder, or substance abuse, TBI or progressive brain disease * stroke prior to the onset of COVID * current substance abuse disorder * prior cognitive processing speed training on DoubleDecision or similar program * cannot tolerate trans-auricular vagus nerve stimulation |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | University of Alabama at Birmingham |
| Locations | Birmingham, Alabama, United States |
| Start date | 2024-04-25 |
| NCT ID | NCT06095297 |
| Official listing | https://clinicaltrials.gov/study/NCT06095297 |