Long-term Adaptations of Skeletal Muscle After Hybrid Training
Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with overweight or obesity, even in the absence of dietary intake manipulation. Hybrid type training
| Condition(s) | Obesity & Overweight |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with overweight or obesity, even in the absence of dietary intake manipulation. Hybrid type training represents a form of HIIT, that incorporates both cardiorespiratory and musculoskeletal stimuli, by combining multiple types of exercise into a circuit-type, interval style workout. Recent evidence suggests that long-term participation in hybrid HIIT results in significant health-related benefits. However, the molecular mechanisms driving the chronic effects of hybrid HIIT on cardiometabolic and musculoskeletal health remains to be elucidated. |
| Who can participate | Inclusion Criteria: * BMI: \>25 kg/m2 and \<40 kg/m2 * Untrained individuals (abstain \>1 year from exercise training) * No dietary intervention over the last 6 months preceding the study * Low cardiorespiratory fitness level (VO2max: \<45 ml/kg/min) * No use of any medication, dietary supplements * Low risk for cardiovascular disease * A weight loss \<10% over the last 6 months preceding the study * Free of non-communicable diseases (excluding metabolic syndrome) Exclusion Criteria: * Low participation rate (\<80% completion of the exercise training sessions) * Unbalanced diet * Participation in additional exercise training regimes * Cosumption of anti-inflammatory of pain relief medication |
| Ages | 30 Years to 50 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Thessaly |
| Locations | Trikala, Thessaly, Greece |
| Start date | 2026-01-08 |
| NCT ID | NCT07341711 |
| Official listing | https://clinicaltrials.gov/study/NCT07341711 |