Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy
The purpose of this study is to learn about possible changes in cognitive (mental) abilities, such as memory skills and concentration, and in brain anatomy (structure) and function, in people with lymphoma receiving CAR-T therapy.
| Condition(s) | Lymphoma Receiving CAR-T Therapy |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The purpose of this study is to learn about possible changes in cognitive (mental) abilities, such as memory skills and concentration, and in brain anatomy (structure) and function, in people with lymphoma receiving CAR-T therapy. |
| Who can participate | Inclusion Criteria: * Patients must be 18 years of age or older * Planned treatment with commercial CD19-specific CAR T cells (axicabtagene ciloleucel, tisagenlecleucel, lisocabtagene maraleucel, or brexacabtagene autoleucel) for lymphoma. * Patients must have adequate end organ function for CAR T cell therapy * Eastern Cooperative Group (ECOG) performance status of 0 to 2 * Meet cardiac, pulmonary, hematologic, hepatic, and renal requirements for CART therapy as described in corresponding product package insert * No evidence of central nervous system disease at study entry * Fluent and able to communicate well enough in English to complete the study assessments and provide informed consent, in the judgment of the consenting professional. o Patients who report that English is not their pri |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Memorial Sloan Kettering Cancer Center |
| Locations | New York, New York, United States |
| Start date | 2019-09-25 |
| NCT ID | NCT04107285 |
| Official listing | https://clinicaltrials.gov/study/NCT04107285 |