Low-intensity Physical-cognitive Exercise and Cognitive Function
This study aims to examine the effects of low-intensity, combined physical-cognitive exercise on cognitive function of older people with mild cognitive impairment (MCI) and identify the mechanisms by which this exercise protocol exerts cognitive function. Older adults with MCI will be recruited to either an exercise or
| Condition(s) | Mild Cognitive Impairment |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study aims to examine the effects of low-intensity, combined physical-cognitive exercise on cognitive function of older people with mild cognitive impairment (MCI) and identify the mechanisms by which this exercise protocol exerts cognitive function. Older adults with MCI will be recruited to either an exercise or a control group. Low-intensity, combined physical-cognitive exercise will be prescribed to the exercise group 3 times per week for 3 months while the control group will maintain their routine lifestyle. It is hypothesized that at the end of the trial, participants in the exercise group will demonstrate significant improvement in cognitive performance and circulating biomarkers compared to baseline and the control group. |
| Who can participate | Inclusion Criteria: * meeting the criteria for MCI (or mNCD) based on the recent DSM-V criteria * comprehend instructions and able to comply with the study procedures * not taking any medications for their cognition and not planning to start medications during the study trial Exclusion Criteria: * presence of medical condition(s) unsafe to exercise or affect cognition and mobility * presence of depressive symptoms * exercise regularly |
| Ages | 60 Years |
| Sex | All |
| Lead sponsor | Chiang Mai University |
| Locations | Chiang Mai, Thailand |
| Start date | 2024-04-07 |
| NCT ID | NCT06201533 |
| Official listing | https://clinicaltrials.gov/study/NCT06201533 |