Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress: deficiencies in essential amino acids, and some micronutrients have an important impact and may
| Condition(s) | Malnutrition, Sarcopenia |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress: deficiencies in essential amino acids, and some micronutrients have an important impact and may induce immune cell dysregulation. Mitochondrial dysfunction may explain the complex relationship between malnutrition sarcopenia, immune dysfunction and aging. Therefore, a personalized nutritional strategy aiming to improve mitochondrial function, decrease oxidative stress, down-regulate inflammation and restore immunity appears to be a logical approach in order to treat malnutrition and its biological and clinical consequences. MIMOSA will investigate the role of nutrition |
| Who can participate | Inclusion Criteria: * Age ≥75 years * Patients entering a rehabilitation program * Diagnosis of malnutrition defined by a MNA-SF (mini-nutritional assessment short form) score below 11 points. * Commitment to accept the nutritional supplement proposed, willing and able to give written informed consent * Ability to understand and comply with the requirements of the study Exclusion Criteria: * Presence of malignancy, * Life expectancy of less than two months calculated by Multidimensional Prognostic Index (MPI ), * Congestive heart failure (NYHA IV), * Chronic renal disease (creatinine clearance \<40 ml/min calculated by cockroft), * Liver cirrhosis (Child B-C), * Tube/percutaneous endoscopic gastrostomy feeding or parenteral nutrition, * Severe dysphagia, * Mini-Mental State Examination (MM |
| Ages | 75 Years |
| Sex | All |
| Lead sponsor | Patrizia D'Amelio |
| Locations | Lausanne, Switzerland, Switzerland |
| Start date | 2025-04-01 |
| NCT ID | NCT05324475 |
| Official listing | https://clinicaltrials.gov/study/NCT05324475 |