Mechanisms of Persistent Fatigue
Persistent fatigue (PF) is a common symptom across countries and cultures, and an important cause of disability and reduced quality of life. Acute infection is a common trigger of PF, as exemplified by the 'Long COVID' phenomenon. Despite substantial burden for the suffering individuals as well as their next-of-kins, t
| Condition(s) | Fatigue Post Viral |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Persistent fatigue (PF) is a common symptom across countries and cultures, and an important cause of disability and reduced quality of life. Acute infection is a common trigger of PF, as exemplified by the 'Long COVID' phenomenon. Despite substantial burden for the suffering individuals as well as their next-of-kins, the healthcare systems and the economy, PF is an under-researched field, with scarce knowledge of disease mechanisms as well as treatment and preventive measures. Existing knowledge on PF suggests complex interactions between functional brain processes (as opposed to permanent brain damage), aberrations of the immune system (that normally protects against infection) and the autonomic (or non-voluntary) part of the nervous system (that monitors the internal state of the body an |
| Who can participate | Inclusion Criteria (pertaining to EBV group only): * EBV infection, laboratory confirmed. * First symptoms \> 3 and \< 6 weeks away Exclusion Criteria (pertaining to both groups) * Co-morbidity, including mental illness (seasonal allergy/asthma is accepted if no signs/symptoms) * Usage of pharmaceuticals (hormonal contraception and paracetamol/ibuprofen is accepted) * Concurrent demanding life event causing fatigue. * Disability impacting on daily living. * Regular smoking * Usage of illicit drugs * Pregnancy |
| Ages | 16 Years to 39 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University Hospital, Akershus |
| Locations | Lørenskog, Norway |
| Start date | 2026-04-28 |
| NCT ID | NCT07394855 |
| Official listing | https://clinicaltrials.gov/study/NCT07394855 |