MEN-ENDO: Menstrual Stem Cells in Endometriosis
Endometriosis is a chronic inflammatory condition characterized by the presence of endometrium-like tissue outside the uterine cavity. It is estimated to affect approximately 10% of women of reproductive age and it is associated with chronic pelvic pain and infertility, among other symptoms. Endometriosis involves comp
| Condition(s) | Endometriosis |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Endometriosis is a chronic inflammatory condition characterized by the presence of endometrium-like tissue outside the uterine cavity. It is estimated to affect approximately 10% of women of reproductive age and it is associated with chronic pelvic pain and infertility, among other symptoms. Endometriosis involves complex changes in the body's cells and immune response. For this reason, the goal of this observational study is to characterize the functional, molecular, and immunological alterations in menstrual blood-derived stem cells (MenSCs) and differentiated decidual stromal cells in women with endometriosis; to validate these findings in endometrial tissue and endometriomas; and to establish their correlation with clinical parameters, with the aim of identifying key pathogenic mechani |
| Who can participate | Inclusion Criteria: * 18-45 years. * Endometriosis group: Women with clinical and/or ecographical diagnostic of endometriosis. * Control group: Women with the endometriosis diagnosis. Exclusion Criteria: * \<18 years or \>45 years. * Pregnancy or lactation. * Diagnosis of prior chronic pelvic inflammatory or autoimmune disease. * History of active gynecological cancer. * Positive for human immunodeficiency virus (HIV) or human papillomavirus (HPV). * Hormonal therapy use in the previous 3 months. * Use of immunosuppressants or corticosteroids in the previous 3 months. * Systemic antibiotics use in the previous 3 months. * Insufficient menstrual flow to allow the MenSCs isolation. |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Francisco Algaba Chueca |
| Locations | Reus, Tarragona, Spain; Tarragona, Tarragona, Spain |
| Start date | 2026-04 |
| NCT ID | NCT07578480 |
| Official listing | https://clinicaltrials.gov/study/NCT07578480 |