Metformin Safety and Efficacy in Osteoarthritis.
Knee osteoarthritis (OA) is a chronic, painful disease associated with considerable morbidity, costs and disability. It is estimated that over a third of people aged over 60 have radiographic knee OA2 and over 50% of these with knee OA will go on to have a total knee replacement in their lifetime. At present there are
| Condition(s) | Osteo Arthritis Knee |
|---|---|
| Status | Recruiting |
| Phase | Phase 3 |
| Study type | Interventional |
| Summary | Knee osteoarthritis (OA) is a chronic, painful disease associated with considerable morbidity, costs and disability. It is estimated that over a third of people aged over 60 have radiographic knee OA2 and over 50% of these with knee OA will go on to have a total knee replacement in their lifetime. At present there are no licensed treatments that alter disease progress and management is primarily concerned with symptom control to retain or improve joint function, although a trial of strontium ranelate showed promising results. |
| Who can participate | Inclusion Criteria: * Primary osteoarthritis Patients recruited were between 30 to 60 years of age. * X-ray confirmed Kellgren-Lawrence grade II or III severity primary tibiofemoral OA according to the American College of Rheumatology criteria. Exclusion Criteria: Patients with age less than 30 years or more than 60 years Patients Presented with active concomitant gastroduodenal disorders, hepatic and renal impairment within last 30 days prior to receiving the study drug Patients Were diagnosed to have any inflammatory arthritis, gout or acute trauma of the knee, hip or spine; accompanying OA of the hip of sufficient severity to interfere with the functional assessment of the knee Patients had previous or ongoing treatment with oral SYSDOA (e.g., glucosamine sulphate, chondroitin sulphate, |
| Ages | 30 Years to 60 Years |
| Sex | All |
| Lead sponsor | Mostafa Bahaa |
| Locations | Damietta, New Damietta, Egypt |
| Start date | 2024-01-30 |
| NCT ID | NCT06231758 |
| Official listing | https://clinicaltrials.gov/study/NCT06231758 |