Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics Project
This study will explore potential links between atopic dermatitis and food allergy. This information will be useful to determine atopic dermatitis and food allergy share unique biochemical or genetic identifiers useful for diagnosing and treatments in the future. This is a mechanistic study consisting of obtaining bloo
| Condition(s) | Atopic Dermatitis, Food Allergy, Healthy |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study will explore potential links between atopic dermatitis and food allergy. This information will be useful to determine atopic dermatitis and food allergy share unique biochemical or genetic identifiers useful for diagnosing and treatments in the future. This is a mechanistic study consisting of obtaining blood and skin samples from participants at baseline. Individuals may also undergo a clinically indicated oral food challenge and have blood and skin samples collected at various times during the oral food challenge. This study will create a molecular map of the pathology of atopic dermatitis and food allergy. This information will be deployed to evaluate the hypothesis that atopic dermatitis and food allergy share unique genetic transcriptional signals in which the study team ca |
| Who can participate | Food allergy-only group Inclusion Criteria: * Have a known history of food anaphylaxis to peanut, tree nut, egg, milk, or sesame confirmed by an allergist. * Have had skin and blood food allergy testing to the food allergen in question within the past 6 months. Meet the 80% likelihood positive predictive value threshold for allergy based on at least 1 of either the skin or blood immunoglobulin E (IgE) tests per current literature corrected for age. See protocol for more details. * No history of atopic dermatitis Food allergy plus atopic dermatitis group Inclusion Criteria: \- Meet the "food allergy only group" inclusion criteria except this group must also have atopic dermatitis. Atopic dermatitis without food allergy Inclusion Criteria: * Have a present diagnosis of atopic dermatitis by a |
| Ages | 10 Years to 55 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Michigan |
| Locations | Ann Arbor, Michigan, United States |
| Start date | 2024-02-15 |
| NCT ID | NCT06300697 |
| Official listing | https://clinicaltrials.gov/study/NCT06300697 |