Modeling and Closed-loop Control of Depth of Anaesthesia
The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing algorithms for better and safer administration of anaesthetic agents.
| Condition(s) | The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing algorithms for better and safer administration of anaesthetic agents. |
| Who can participate | Inclusion Criteria: * patients having vitroretinal surgery in general anaesthesia * patients having brain surgery in general anaesthesia * patients needing sedation in ICU * ASA 1-3 Exclusion Criteria: * ASA \> 3 * BMI \> 35 * drug addicts * patients taking psychotropic medicines * patients taking opioid analgesics (including tramadol) * severe psychiatric disease * central nervous system disease (except the reason for surgery) * arrhythmia affecting or preventing the measurements (e.g. chronic atrial fibrillation) * patients that received benzodiazepines |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Ljubljana |
| Locations | Ljubljana, Ljubljana, Slovenia |
| Start date | 2017-09-14 |
| NCT ID | NCT03569839 |
| Official listing | https://clinicaltrials.gov/study/NCT03569839 |