Modulate Tremor Severity With Low-intensity Focused Ultrasound Stimulation Targeting the D
The study plans to recruit 12 patients with Parkinsonian tremor, essential tremor, or dystonic tremor. After receiving NaviFUS-ctbTUS stimulation, the improvement in their tremor will be recorded.
| Condition(s) | Parkinson Disease (PD), Essential Tremor, Dystonic Tremor, Continuous Theta Burst Stimulation Transcranial Focused Ultrasound |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The study plans to recruit 12 patients with Parkinsonian tremor, essential tremor, or dystonic tremor. After receiving NaviFUS-ctbTUS stimulation, the improvement in their tremor will be recorded. |
| Who can participate | Inclusion Criteria: * Age between 18 and 80 years. * Subjects must belong to one of the following three categories: 1. Patients with Parkinson's disease tremor who have an inadequate response to medication. 2. Patients with essential tremor who have an inadequate response to medication. 3. Patients with dystonic tremor who have an inadequate response to medication. * Subjects are willing to shave hair over the treatment area for focused ultrasound. * Stable medication regimen (types and dosages) for at least 4 weeks prior to study enrollment. * Normal liver and renal function (Creatinine \< 1.3 mg/dL, GPT \< 41 U/L). * Female participants of childbearing potential, or male participants with female partners of childbearing potential, must agree to use appropriate contraception from the firs |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Lead sponsor | National Taiwan University Hospital |
| Locations | Hsinchu, Hsinchu City, Taiwan |
| Start date | 2025-06-11 |
| NCT ID | NCT07172295 |
| Official listing | https://clinicaltrials.gov/study/NCT07172295 |