Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brai
The purpose of this study is to prospectively collect specimens from pediatric patients with diffuse intrinsic pontine glioma or brainstem glioma, either during therapy or at autopsy, in order to characterize the molecular abnormalities of this tumor.
| Condition(s) | Diffuse Intrinsic Pontine Glioma, Brainstem Glioma |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The purpose of this study is to prospectively collect specimens from pediatric patients with diffuse intrinsic pontine glioma or brainstem glioma, either during therapy or at autopsy, in order to characterize the molecular abnormalities of this tumor. |
| Who can participate | Inclusion Criteria: * Patients of any age with clinical and radiologic diagnosis of diffuse intrinsic pontine glioma * Patients with other high-grade gliomas originating in the brainstem * Patients with focal gliomas (WHO grade I/II) of the brainstem Exclusion Criteria: * Patients with any type of infiltrative low grade (WHO grade I and II) or high grade glioma (WHO grade III and IV) originating outside the brainstem * Patients harboring primary brainstem tumors with other histologic diagnoses (e.g., PNET) |
| Ages | 21 Years |
| Sex | All |
| Lead sponsor | Children's National Research Institute |
| Locations | Washington D.C., District of Columbia, United States |
| Start date | 2010-04 |
| NCT ID | NCT01106794 |
| Official listing | https://clinicaltrials.gov/study/NCT01106794 |