Molecular Basis of Human Phagocyte Interactions With Bacterial Pathogens
Human phagocytic cells such as polymorphonuclear leukocytes (PMNs) are readily mobilized to sites of infection and ingest microorganisms by a process known as phagocytosis. The combined effects of reactive oxygen species (ROS) and proteolytic peptides and enzymes released into forming bacterial phagosomes kill most ing
| Condition(s) | Host Defense Mechanisms |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Human phagocytic cells such as polymorphonuclear leukocytes (PMNs) are readily mobilized to sites of infection and ingest microorganisms by a process known as phagocytosis. The combined effects of reactive oxygen species (ROS) and proteolytic peptides and enzymes released into forming bacterial phagosomes kill most ingested bacteria. However, many human bacterial pathogens have devised means to subvert normal phagocyte responses and the innate immune response and cause severe disease. The overall objective of this study is to elucidate specific features of pathogen-phagocyte interactions that underlie evasion of the innate immune response or contribute to the pathophysiology of disease or inflammatory disorders. Therefore, specific projects will: 1. Identify and characterize specific mecha |
| Who can participate | * INCLUSION \& EXCLUSION CRITERIA: Volunteers will be selected from a healthy adult population, 18 years of age or older, with no known medical problems and will generally be NIH employees working at Rocky Mountain Laboratories (RML) or within the community of Hamilton, MT. No race or gender is excluded from the donor pool and reflects the diversity of the community and that of the employees at RML. The specific criteria for eligibility are as follows: * Subjects must fit the definition of "healthy adults" as assessed by the medical/health screening evaluations, and willing to have blood and/or tissue samples stored for future use. * Inasmuch as all subjects are RML employees, they will be 18 years of age or older. * Children are excluded. * Pregnant women will be identified by verbal hist |
| Ages | 18 Years to 120 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
| Locations | Hamilton, Montana, United States |
| Start date | 2001-02-12 |
| NCT ID | NCT00339287 |
| Official listing | https://clinicaltrials.gov/study/NCT00339287 |