MRI Guided Closed-loop TMS-EEG
The goal of this interventional study is to develop an individualized approach using transcranial magnetic stimulation (TMS) in a high-precision manner. This approach will use TMS to modulate brain activity at multiple locations simultaneously. Functional magnetic resonance imaging (fMRI) and electroencephalograph (EEG
| Condition(s) | Normal Physiology, Amnestic Mild Cognitive Impairment |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this interventional study is to develop an individualized approach using transcranial magnetic stimulation (TMS) in a high-precision manner. This approach will use TMS to modulate brain activity at multiple locations simultaneously. Functional magnetic resonance imaging (fMRI) and electroencephalograph (EEG) will record the responses and guide the stimulation. Specifically, the placement and orientation of TMS coils will be tailored to stimulate the targeted functional brain areas informed by fMRI. To maximize the interventional effect, stimulation pulses will be delivered based on EEG oscillations. |
| Who can participate | Inclusion Criteria for Healthy participants: * Ages between 18 and 65 years; * Healthy with no history of neurological impairment; * Normal or correct-to-normal vision. Inclusion Criteria for aMCI patients: * Age 50-80 years; * MCI clinical criteria: (a) self- or informant-reported cognitive complaint; (b) preserved independence in functional abilities; and (c) absence of dementia; * Objective cognitive impairment supported by the following measures of general cognitive function: (a) Mini-Mental State Exam (MMSE) 24-27 (inclusive); (b) Montreal Cognitive Assessment (MoCA) 18-26 (inclusive); or (c) Clinical Dementia Rating Scale score of 0.5; * Normal or correct-to-normal vision. Exclusion Criteria for all participants: * Women who are pregnant or breastfeeding; * History of seizure (childh |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Sunnybrook Health Sciences Centre |
| Locations | Toronto, Ontario, Canada |
| Start date | 2023-09-07 |
| NCT ID | NCT06050603 |
| Official listing | https://clinicaltrials.gov/study/NCT06050603 |