MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are: 1. Neurometabolic predictors of early neurological deterioration and functional out
| Condition(s) | Acute Ischemic Stroke |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are: 1. Neurometabolic predictors of early neurological deterioration and functional outcome; 2. Temporal and spatial dynamic changes of the neurometabolites from the acute stage (within 24 hours), through the subacute stage (5-7 days), to the chronic stage (90 days); 3. Temporal and spatial dynamic changes of the neurotransmitters GABA, glutamate, and glutamine from the acute stage to the chronic stage; 4. Brain regions exhibiting changes in whole-brain metabolic network connectivity. |
| Who can participate | Inclusion Criteria: 1. Adult (age ≥ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery; 2. Patients with mild symptoms at admission (National Institutes of Health Stroke Scale (NIHSS)\<6); 3. Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital; 4. Time from symptom onset or last known normal to enrollment is less than 24 hours; 5. Patient or legal representative willing to comply with protocol requirements and data collection procedures, understand and sign informed consent. Exclusion Criteria: 1. A pre-incident mRS ≥ 1 point before onset; 2. Previous clear history of cerebral infarction, cerebral hem |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Lead sponsor | Shanghai 6th People's Hospital |
| Locations | Shanghai, Shanghai Municipality, China |
| Start date | 2024-08-15 |
| NCT ID | NCT06457217 |
| Official listing | https://clinicaltrials.gov/study/NCT06457217 |